Unfortunately I've run into people like that playing Destiny on the few occasions I played with random people. I did end up with a bunch of guys in my province somehow, and most of them spoke french but there was one who spoke english. He was nice and translated things, and talked to me normally, but occasionally I heard my username mentioned and they'd start laughing. I didn't care that much cause I didn't know what they were saying. I friended the nice guy and I joined him another time. Unfortunately some douche bag came in and tried SO hard to look cool, talking about drugs and how much of a "hard ass" he was. When I finally talked and he knew I was a girl, he only got worse and started talking about sexual stuff and asked me gross questions. I never played with them again. I didn't feel personally attacked or anything, but it was just a huge turn off. I want to play a game, not babysit man-babies trying to look cool for a girl.
Now I pretty much just play with friends, and friends of friends. Or, in the case of PS4 with their group chat feature that doesn't require you to be tethered by game, just talk to them while I do my own thing. Last night I did that with Cadoca (on this forum), her husband, and their friend Ty. I've played with both guys on several occasions before and they can manage being a decent human being, so why can't the rest? >.>